› 5m5q

X-ray diffraction
2.2Å resolution

COPS5(2-257) IN COMPLEX WITH A AZAINDOLE (COMPOUND 4)

Released:
DOI: 10.2210/pdb5m5q/pdb
PDB entry 5m5q coloured by chain, front view.
PDB entry 5m5q coloured by chain, side view.
PDB entry 5m5q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.
Altmann E, Erbel P, Renatus M, Schaefer M, Schlierf A, Druet A, Kieffer L, Sorge M, Pfister K, Hassiepen U, Jones M, Ruedisser S, Ostermeier D, Martoglio B, Jefferson AB, Quancard J
Angew. Chem. Int. Ed. Engl. (2016)
PMID: 27981705

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
COP9 signalosome complex subunit 5 Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 28.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92905 (Residues: 2-257; Coverage: 77%)
Gene names: COPS5, CSN5, JAB1
Sequence domains: JAB1/Mov34/MPN/PAD-1 ubiquitin protease

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand 7K1 1 x 7K1
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: I4
Unit cell:
a: 102.365Å b: 102.365Å c: 69.048Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.197 0.219
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease.
Sherman et al. (2020)
5 more

3 mentions without citation

On the Study of Deubiquitinases: Using the Right Tools for the Job.
Caba et al. (2022)
2 more