› 5m7m

X-ray diffraction
2.7Å resolution

Function and Biology Details

Reaction catalysed: 
1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171821 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Chain: A
Molecule details ›
Chain: A
Length: 871 amino acids
Theoretical weight: 100.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13822 (Residues: 1-863; Coverage: 100%)
Gene names: ATX, ENPP2, PDNP2
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
8 bound ligands:
Ligand 7HR 1 x 7HR
Ligand IOD 1 x IOD
Ligand CL 2 x CL
Ligand SCN 1 x SCN
Ligand NI 7 x NI
Ligand PO4 1 x PO4
Ligand K 1 x K
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21
Unit cell:
a: 77.45Å b: 78.89Å c: 78.57Å
α: 90° β: 91.87° γ: 90°
R-values:
R R work R free
0.232 0.229 0.284
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Design and Development of Autotaxin Inhibitors.
Jia et al. (2021)
1 more