› 5m9r

X-ray diffraction
1.44Å resolution

Human angiogenin ALS variant F100I

Released:
DOI: 10.2210/pdb5m9r/pdb
PDB entry 5m9r coloured by chain, front view.
PDB entry 5m9r coloured by chain, side view.
PDB entry 5m9r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Bradshaw WJ, Rehman S, Pham TT, Thiyagarajan N, Lee RL, Subramanian V, Acharya KR
Sci Rep 7 41996 (2017)
PMID: 28176817

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiogenin Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 14.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03950 (Residues: 25-147; Coverage: 100%)
Gene names: ANG, RNASE5
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

3 bound ligands:
Ligand TAR 2 x TAR
Ligand TLA 2 x TLA
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P1
Unit cell:
a: 30.878Å b: 34.781Å c: 52.92Å
α: 89.72° β: 84.17° γ: 84.34°
R-values:
R R work R free
0.173 0.172 0.195
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Motor Neuron Susceptibility in ALS/FTD.
Ragagnin et al. (2019)
8 more

1 mention without citation

Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Bradshaw et al. (2017)