› 5m9s

X-ray diffraction
1.85Å resolution

Human angiogenin ALS variant V103I

Released:
DOI: 10.2210/pdb5m9s/pdb
PDB entry 5m9s coloured by chain, front view.
PDB entry 5m9s coloured by chain, side view.
PDB entry 5m9s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Bradshaw WJ, Rehman S, Pham TT, Thiyagarajan N, Lee RL, Subramanian V, Acharya KR
Sci Rep 7 41996 (2017)
PMID: 28176817

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiogenin Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03950 (Residues: 25-147; Coverage: 100%)
Gene names: ANG, RNASE5
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

1 bound ligand:
Ligand TAR 1 x TAR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2221
Unit cell:
a: 82.749Å b: 115.906Å c: 37.288Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.208 0.264
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Motor Neuron Susceptibility in ALS/FTD.
Ragagnin et al. (2019)
8 more

1 mention without citation

Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Bradshaw et al. (2017)