› 5mev

X-ray diffraction
2.94Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211543 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1; Induced myeloid leukemia cell differentiation protein Mcl-1 homolog Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 18.23 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P97287 (Residues: 153-221; Coverage: 21%)
  • Canonical: Q07820 (Residues: 241-327; Coverage: 25%)
Gene names: BCL2L3, MCL1, Mcl1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Fab Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 230 amino acids
Theoretical weight: 24.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Fab Light Chain Chain: L
Molecule details ›
Chain: L
Length: 226 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand 7LW 1 x 7LW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 166.514Å b: 39.705Å c: 103.515Å
α: 90° β: 125.74° γ: 90°
R-values:
R R work R free
0.229 0.225 0.302
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy.
Hengel et al. (2017)
7 more

2 mentions without citation

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.
Johannes et al. (2017)
1 more