› 5mgl

X-ray diffraction
2.65Å resolution

Crystal Structure of BAZ2A bromodomain in complex with 4-chloropyridine derivative 3

Released:
DOI: 10.2210/pdb5mgl/pdb
PDB entry 5mgl coloured by chain, front view.
PDB entry 5mgl coloured by chain, side view.
PDB entry 5mgl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of BAZ2A bromodomain ligands.
Spiliotopoulos D, Wamhoff EC, Lolli G, Rademacher C, Caflisch A
Eur J Med Chem 139 564-572 (2017)
PMID: 28837921

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193785 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain adjacent to zinc finger domain protein 2A Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 12.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UIF9 (Residues: 1796-1898; Coverage: 5%)
Gene names: BAZ2A, KIAA0314, TIP5
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand 7MU 1 x 7MU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P3121
Unit cell:
a: 95.55Å b: 95.55Å c: 32.84Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.213 0.253
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Targeting bromodomain-containing proteins: research advances of drug discovery.
Pan et al. (2023)
8 other articles

2 mentions without citation

Application of Genomics Tools in Wheat Breeding to Attain Durable Rust Resistance.
Babu et al. (2020)
1 more