› 5mhm

X-ray diffraction
2.12Å resolution

FXIIIa in complex with the inhibitor ZED1630

Released:
DOI: 10.2210/pdb5mhm/pdb
PDB entry 5mhm coloured by chain, front view.
PDB entry 5mhm coloured by chain, side view.
PDB entry 5mhm coloured by chain, top view.
Source organisms:
Entry authors: Stieler M, Heine A, Klebe G

Function and Biology Details

Reaction catalysed: 
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)-(gamma-glutamyl)-L-lysine cross-link + NH(3)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132551 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Coagulation factor XIII A chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 738 amino acids
Theoretical weight: 84.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00488 (Residues: 2-732; Coverage: 100%)
Gene names: F13A, F13A1
Sequence domains:
Structure domains:
inhibitor ZED1630 Chains: H, O
Molecule details ›
Chains: H, O
Length: 8 amino acids
Theoretical weight: 935 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

4 bound ligands:
Ligand CA 6 x CA
Ligand GOL 6 x GOL
Ligand CL 2 x CL
Ligand SO4 5 x SO4
1 modified residue:
Ligand NLE 2 x NLE

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P1
Unit cell:
a: 56.912Å b: 80.715Å c: 103.19Å
α: 88.44° β: 76.6° γ: 81.79°
R-values:
R R work R free
0.172 0.17 0.213
Expression systems:
  • Spodoptera frugiperda
  • Not provided

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