Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Interleukin-23 complex and unmapped proteins (preferred)
PDBe Complex ID:
PDB-CPX-151476 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Interleukin-12 subunit beta
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Cytokine interleukin-12p40 C-terminus
Structure domains: Immunoglobulins
Length: 306 amino acids
Theoretical weight: 34.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P29460 (Residues: 23-328; Coverage: 100%)
Sequence domains: Cytokine interleukin-12p40 C-terminus
Structure domains: Immunoglobulins
Interleukin-23 subunit alpha
Molecule details ›
Chain: B
Length: 179 amino acids
Theoretical weight: 19.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Interleukin 23 subunit alpha
Structure domains: Growth Hormone; Chain: A;
Length: 179 amino acids
Theoretical weight: 19.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9NPF7 (Residues: 20-189; Coverage: 100%)
Sequence domains: Interleukin 23 subunit alpha
Structure domains: Growth Hormone; Chain: A;
Ligands and Environments
Experiments and Validation Details
X-ray source:
SLS BEAMLINE X06SA
Spacegroup:
P41212
Expression systems:
- Homo sapiens
- Escherichia coli BL21(DE3)
