PDB 5mjt structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reaction catalysed:

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

Biochemical function:

serine-type endopeptidase activity

Biological process:

blood coagulation

Cellular component:

extracellular region

Sequence domains:

1 more domain

Structure analysis Details

Assembly composition:

hetero trimer (preferred)

Assembly name:

alpha-thrombin complex and Hirudin variant-2 (preferred)

PDBe Complex ID:

PDB-CPX-133076 (preferred)

Entry contents:

3 distinct polypeptide molecules

Macromolecules (3 distinct):

Thrombin light chain Chain: L

Molecule details ›

Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P00734 (Residues: 328-363; Coverage: 6%)

Gene name: F2
Sequence domains: Thrombin light chain

Thrombin heavy chain Chain: H

Molecule details ›

Chain: H
Length: 259 amino acids
Theoretical weight: 29.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P00734 (Residues: 364-622; Coverage: 43%)

Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Hirudin variant-2 Chain: D

Molecule details ›

Chain: D
Length: 12 amino acids
Theoretical weight: 1.55 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt: