› 5mkj

X-ray diffraction
2.5Å resolution

Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 9 and a fragment of the TIF2 co-activator.

Released:
DOI: 10.2210/pdb5mkj/pdb
PDB entry 5mkj coloured by chain, front view.
PDB entry 5mkj coloured by chain, side view.
PDB entry 5mkj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
Scheepstra M, Andrei SA, de Vries RMJM, Meijer FA, Ma JN, Burstein ES, Olsson R, Ottmann C, Milroy LG, Brunsveld L
ACS Chem Neurosci 8 2065-2077 (2017)
PMID: 28691794

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148721 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chain: A
Molecule details ›
Chain: A
Length: 230 amino acids
Theoretical weight: 25.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 229-458; Coverage: 50%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 1.14 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand 4CU 1 x 4CU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: P43212
Unit cell:
a: 64.139Å b: 64.139Å c: 111.979Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.193 0.245
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation.
De Bosscher et al. (2020)
1 more

1 mention without citation

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
Scheepstra et al. (2017)