› 5mku

X-ray diffraction
1.78Å resolution

Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 4 and a fragment of the TIF2 co-activator.

Released:
DOI: 10.2210/pdb5mku/pdb
PDB entry 5mku coloured by chain, front view.
PDB entry 5mku coloured by chain, side view.
PDB entry 5mku coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
Scheepstra M, Andrei SA, de Vries RMJM, Meijer FA, Ma JN, Burstein ES, Olsson R, Ottmann C, Milroy LG, Brunsveld L
ACS Chem Neurosci 8 2065-2077 (2017)
PMID: 28691794

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148722 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 25.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 229-456; Coverage: 49%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP-SER Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.36 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand J57 1 x J57
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-003
Spacegroup: P3221
Unit cell:
a: 77.65Å b: 77.65Å c: 81.241Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.149 0.148 0.177
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation.
De Bosscher et al. (2020)
1 more

2 mentions without citation

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
Scheepstra et al. (2017)
1 more