› 5mo3

X-ray diffraction
1.69Å resolution

Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 8.5

Released:
DOI: 10.2210/pdb5mo3/pdb
PDB entry 5mo3 coloured by chain, front view.
PDB entry 5mo3 coloured by chain, side view.
PDB entry 5mo3 coloured by chain, top view.
Source organisms:
Entry authors: Skrabana R, Novak M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210470 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Microtubule-associated protein tau Chain: A
Molecule details ›
Chain: A
Length: 14 amino acids
Theoretical weight: 1.47 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 615-628; Coverage: 2%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Fab of monoclonal antibody, heavy chain Chain: H
Molecule details ›
Chain: H
Length: 221 amino acids
Theoretical weight: 23.8 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Fab of monoclonal antibody, light chain Chain: L
Molecule details ›
Chain: L
Length: 218 amino acids
Theoretical weight: 24.17 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
1 bound ligand:
Ligand PGE 4 x PGE
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 58.728Å b: 60.128Å c: 69.315Å
α: 90° β: 109.25° γ: 90°
R-values:
R R work R free
0.192 0.189 0.235
Expression system: Not provided

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