5moi

X-ray diffraction
2.2Å resolution

Crystal structure of human IgE-Fc epsilon 3-4

Released:
Source organism: Homo sapiens
Primary publication:
Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.
Biochim Biophys Acta Proteins Proteom 1865 1336-1347 (2017)
PMID: 28844738

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
PDBe Complex ID:
PDB-CPX-134809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
Immunoglobulin heavy constant epsilon Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 223 amino acids
Theoretical weight: 24.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01854 (Residues: 209-427; Coverage: 40%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: BMA, MAN
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P1
Unit cell:
a: 47.673Å b: 90.296Å c: 92.908Å
α: 114.41° β: 90.63° γ: 96.1°
R-values:
R R work R free
0.214 0.213 0.234
Expression system: Homo sapiens