› 5mok

X-ray diffraction
2Å resolution

Crystal structure of human IgE-Fc epsilon 3-4

Released:
DOI: 10.2210/pdb5mok/pdb
PDB entry 5mok coloured by chain, front view.
PDB entry 5mok coloured by chain, side view.
PDB entry 5mok coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.
Doré KA, Davies AM, Drinkwater N, Beavil AJ, McDonnell JM, Sutton BJ
Biochim Biophys Acta Proteins Proteom 1865 1336-1347 (2017)
PMID: 28844738

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134808 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Immunoglobulin heavy constant epsilon Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 223 amino acids
Theoretical weight: 24.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01854 (Residues: 209-427; Coverage: 40%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand PEG 2 x PEG
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 66.478Å b: 100.357Å c: 77.856Å
α: 90° β: 97.35° γ: 90°
R-values:
R R work R free
0.204 0.202 0.226
Expression system: Homo sapiens

Quick links

Citations

1 review citation

IgE Antibodies: From Structure to Function and Clinical Translation.
Sutton et al. (2019)
2 other articles

1 mention without citation

Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.
Doré et al. (2017)