› 5mpg

Solution NMR

Solution NMR structure of hnRNP A1 RRM1 in complex with 5'-UUAGGUC-3' RNA

Released:
DOI: 10.2210/pdb5mpg/pdb
PDB entry 5mpg coloured by chain, ensemble of 20 models, front view.
PDB entry 5mpg coloured by chain, ensemble of 20 models, side view.
PDB entry 5mpg coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7.
Beusch I, Barraud P, Moursy A, Cléry A, Allain FH
Elife 6 (2017)
PMID: 28650318

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140722 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09651 (Residues: 2-97; Coverage: 26%)
Gene names: HNRNPA1, HNRPA1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
RNA UUAGGUC Chain: B
Molecule details ›
Chain: B
Length: 7 nucleotides
Theoretical weight: 2.2 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 73%
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

10 review citations

How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms.
Corley et al. (2020)
9 more

5 mentions without citation

Idiosyncrasies of hnRNP A1-RNA recognition: Can binding mode influence function.
Levengood et al. (2019)
4 more