› 5mpk

X-ray diffraction
1.9Å resolution

Crystal structure of CREBBP bromodomain complexed with DK19

Released:
DOI: 10.2210/pdb5mpk/pdb
PDB entry 5mpk coloured by chain, front view.
PDB entry 5mpk coloured by chain, side view.
PDB entry 5mpk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
Zhu J, Dong J, Batiste L, Unzue A, Dolbois A, Pascanu V, Śledź P, Nevado C, Caflisch A
ACS Med Chem Lett 9 929-934 (2018)
PMID: 30258543

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CREB-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 119 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92793 (Residues: 1081-1197; Coverage: 5%)
Gene names: CBP, CREBBP
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand 0BC 2 x 0BC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 45.077Å b: 60.204Å c: 87.636Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.183 0.239
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 citation in other articles

Reevaluation of bromodomain ligands targeting BAZ2A.
Cazzanelli et al. (2023)
2 more

1 mention without citation

Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
Zhu et al. (2018)