› 5mq1

X-ray diffraction
1.5Å resolution

Crystal structure of the BRD7 bromodomain in complex with BI-9564

Released:
DOI: 10.2210/pdb5mq1/pdb
PDB entry 5mq1 coloured by chain, front view.
PDB entry 5mq1 coloured by chain, side view.
PDB entry 5mq1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Diaz-Saez L, Martin LJ, Panagakou I, Picaud S, Krojer T, von Delft F, Knapp S, Arrowsmith CH, Edwards AM, Bountra C, Huber K, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 7 Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 13.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NPI1 (Residues: 128-239; Coverage: 17%)
Gene names: BP75, BRD7, CELTIX1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

5 bound ligands:
Ligand 5U6 1 x 5U6
Ligand ZN 2 x ZN
Ligand CL 3 x CL
Ligand MG 1 x MG
Ligand EDO 11 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2221
Unit cell:
a: 66.87Å b: 125.255Å c: 37.353Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.162 0.19
Expression system: Escherichia coli BL21(DE3)

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