› 5mra

X-ray diffraction
3.74Å resolution

human SCBD (sorcin calcium binding domain) in complex with doxorubicin

Released:
DOI: 10.2210/pdb5mra/pdb
PDB entry 5mra coloured by chain, front view.
PDB entry 5mra coloured by chain, side view.
PDB entry 5mra coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.
Genovese I, Fiorillo A, Ilari A, Masciarelli S, Fazi F, Colotti G
Cell Death Dis 8 e2950 (2017)
PMID: 28726784

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151780 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorcin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 167 amino acids
Theoretical weight: 18.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30626 (Residues: 32-198; Coverage: 84%)
Gene name: SRI
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

3 bound ligands:
Ligand MG 10 x MG
Ligand DMS 1 x DMS
Ligand DM2 1 x DM2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-3
Spacegroup: P212121
Unit cell:
a: 92.229Å b: 104.831Å c: 113.273Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.192 0.285
Expression system: Escherichia coli

Quick links

Citations

4 review citations

In vitro assays and techniques utilized in anticancer drug discovery.
Ediriweera et al. (2019)
3 more

3 mentions without citation

Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.
Genovese et al. (2017)
2 more