› 5mub

X-ray diffraction
3.1Å resolution

ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05)

Released:
DOI: 10.2210/pdb5mub/pdb
PDB entry 5mub coloured by chain, front view.
PDB entry 5mub coloured by chain, side view.
PDB entry 5mub coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R
JCI Insight 2 (2017)
PMID: 28679953

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-219354 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
ACC1 Fab fragment heavy chain Chains: A, C, I, L, O, U
Molecule details ›
Chains: A, C, I, L, O, U
Length: 218 amino acids
Theoretical weight: 23.35 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
ACC1 Fab fragment light chain Chains: B, D, G, J, M, P, S, V
Molecule details ›
Chains: B, D, G, J, M, P, S, V
Length: 218 amino acids
Theoretical weight: 23.72 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Collagen alpha-1(II) chain Chains: E, H, K, N, Q, T, W, X
Molecule details ›
Chains: E, H, K, N, Q, T, W, X
Length: 33 amino acids
Theoretical weight: 3.02 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P28481 (Residues: 546-577; Coverage: 2%)
Gene name: Col2a1
ACC1 Fab fragment heavy chain Chains: F, R
Molecule details ›
Chains: F, R
Length: 220 amino acids
Theoretical weight: 23.57 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
2 modified residues:
Ligand HYP 64 x HYP
Ligand CIR 8 x CIR

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 148.286Å b: 155.099Å c: 156.266Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.231 0.264
Expression system: Not provided

Quick links

Citations

15 review citations

Complement in the Initiation and Evolution of Rheumatoid Arthritis.
Holers et al. (2018)
14 more

1 mention without citation

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge et al. (2017)