› 5mv3

X-ray diffraction
2.95Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-219355 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
heavy chain of ACC1 Fab fragment Chains: A, C, F, I, O, R, U
Molecule details ›
Chains: A, C, F, I, O, R, U
Length: 218 amino acids
Theoretical weight: 23.35 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
light chain of ACC1 Fab fragment Chains: B, D, G, J, M, P, S, V
Molecule details ›
Chains: B, D, G, J, M, P, S, V
Length: 218 amino acids
Theoretical weight: 23.72 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Collagen alpha-1(II) chain Chains: E, H, K, N, Q, T, W, X
Molecule details ›
Chains: E, H, K, N, Q, T, W, X
Length: 30 amino acids
Theoretical weight: 2.7 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P28481 (Residues: 1179-1208; Coverage: 2%)
Gene name: Col2a1
Sequence domains: Collagen triple helix repeat (20 copies)
heavy chain of ACC1 Fab fragment Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 23.57 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 56 x HYP

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P1
Unit cell:
a: 87.353Å b: 92.844Å c: 121.706Å
α: 92.5° β: 106.53° γ: 104.31°
R-values:
R R work R free
0.204 0.202 0.261
Expression system: Not provided

Quick links

Citations

15 review citations

Complement in the Initiation and Evolution of Rheumatoid Arthritis.
Holers et al. (2018)
14 more

1 mention without citation

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge et al. (2017)