› 5n1x

X-ray diffraction
1.72Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154262 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
B-cell lymphoma 6 protein Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 13.98 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P41182 (Residues: 9-128; Coverage: 17%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A
B-cell lymphoma 6 protein Chains: B, C
Molecule details ›
Chains: B, C
Length: 121 amino acids
Theoretical weight: 13.98 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P41182 (Residues: 7-127; Coverage: 17%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A
B-cell lymphoma 6 protein Chain: D
Molecule details ›
Chain: D
Length: 118 amino acids
Theoretical weight: 13.69 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P41182 (Residues: 9-125; Coverage: 17%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

1 bound ligand:
Ligand 8HH 4 x 8HH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P43
Unit cell:
a: 47.936Å b: 47.936Å c: 198.946Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.214
Expression system: Komagataella pastoris

Quick links

Citations

8 review citations

Targeting Transcription Factors for Cancer Treatment.
Lambert et al. (2018)
7 more

1 mention without citation

Progress toward B-Cell Lymphoma 6 BTB Domain Inhibitors for the Treatment of Diffuse Large B-Cell Lymphoma and Beyond.
Ai et al. (2021)