› 5n1z

X-ray diffraction
1.81Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
B-cell lymphoma 6 protein Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P41182 (Residues: 6-128; Coverage: 17%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand 8GQ 1 x 8GQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 30.89Å b: 71.89Å c: 54.95Å
α: 90° β: 105.92° γ: 90°
R-values:
R R work R free
0.218 0.216 0.25
Expression system: Komagataella pastoris

Quick links

Citations

5 review citations

Targeting Transcription Factors for Cancer Treatment.
Lambert et al. (2018)
4 more

5 mentions without citation

Targeting epigenetic protein-protein interactions with small-molecule inhibitors.
Linhares et al. (2020)
4 more