› 5n5a

Solution NMR

Structure of Tau(254-290) bound to F-actin

Released:
DOI: 10.2210/pdb5n5a/pdb
PDB entry 5n5a coloured by chain, ensemble of 20 models, front view.
PDB entry 5n5a coloured by chain, ensemble of 20 models, side view.
PDB entry 5n5a coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau.
Cabrales Fontela Y, Kadavath H, Biernat J, Riedel D, Mandelkow E, Zweckstetter M
Nat Commun 8 1981 (2017)
PMID: 29215007

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145370 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chain: A
Molecule details ›
Chain: A
Length: 37 amino acids
Theoretical weight: 4.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 571-607; Coverage: 5%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 7%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

22 review citations

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease.
Kametani et al. (2018)
21 more

10 mentions without citation

Critical observations that shaped our understanding of the function(s) of intracellular glycosylation (O-GlcNAc).
Zachara NE. (2018)
9 more