5n7e

X-ray diffraction
1.65Å resolution

Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4).

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-145737 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mb(Bcr-DH_4) Chain: A
Molecule details ›
Chain: A
Length: 95 amino acids
Theoretical weight: 10.12 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Breakpoint cluster region protein Chain: B
Molecule details ›
Chain: B
Length: 219 amino acids
Theoretical weight: 24.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11274 (Residues: 487-702; Coverage: 17%)
Gene names: BCR, BCR1, D22S11
Sequence domains: RhoGEF domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 164.122Å b: 55.568Å c: 45.031Å
α: 90° β: 105.46° γ: 90°
R-values:
R R work R free
0.185 0.183 0.219
Expression system: Escherichia coli