5n92

X-ray diffraction
2.3Å resolution

Crystal Structure of Human IL-17AF

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-172494 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-17A Chain: A
Molecule details ›
Chain: A
Length: 132 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q16552 (Residues: 24-155; Coverage: 100%)
Gene names: CTLA8, IL17, IL17A
Sequence domains: Interleukin-17
Structure domains: Cystine-knot cytokines
Interleukin-17F Chain: F
Molecule details ›
Chain: F
Length: 139 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96PD4 (Residues: 31-163; Coverage: 100%)
Gene name: IL17F
Sequence domains: Interleukin-17
Structure domains: Cystine-knot cytokines

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P4122
Unit cell:
a: 87.38Å b: 87.38Å c: 126.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.241
Expression system: Homo sapiens