› 5n9b

X-ray diffraction
1.9Å resolution

Crystal Structure of unliganded human IL-17RA

Released:
DOI: 10.2210/pdb5n9b/pdb
PDB entry 5n9b coloured by chain, front view.
PDB entry 5n9b coloured by chain, side view.
PDB entry 5n9b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.
Goepfert A, Barske C, Lehmann S, Wirth E, Willemsen J, Gudjonsson JE, Ward NL, Sarkar MK, Hemmig R, Kolbinger F, Rondeau JM
Cell Rep 41 111489 (2022)
PMID: 36260993

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188488 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-17 receptor A Chain: A
Molecule details ›
Chain: A
Length: 286 amino acids
Theoretical weight: 33.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96F46 (Residues: 33-318; Coverage: 34%)
Gene names: IL17R, IL17RA
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 40.593Å b: 71.685Å c: 105.385Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.234
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Revisiting the interleukin 17 family of cytokines in psoriasis: pathogenesis and potential targets for innovative therapies.
Brembilla et al. (2023)
1 more

3 mentions without citation

Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8.
Wu et al. (2022)
2 more