› 5nbu

X-ray diffraction
1.67Å resolution

Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations

Released:
DOI: 10.2210/pdb5nbu/pdb
PDB entry 5nbu coloured by chain, front view.
PDB entry 5nbu coloured by chain, side view.
PDB entry 5nbu coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Huntington JA, Pomowski A, Johnson DJD

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133784 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-1-antitrypsin Chain: A
Molecule details ›
Chain: A
Length: 377 amino acids
Theoretical weight: 42.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01009 (Residues: 43-418; Coverage: 95%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand GOL 2 x GOL
Ligand OXM 2 x OXM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 114.1Å b: 39.34Å c: 89.41Å
α: 90° β: 103.7° γ: 90°
R-values:
R R work R free
0.18 0.178 0.228
Expression system: Escherichia coli

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