› 5nh1

X-ray diffraction
2.04Å resolution

Structure of the C-terminal domain of human Gasdermin D

Released:
DOI: 10.2210/pdb5nh1/pdb
PDB entry 5nh1 coloured by chain, front view.
PDB entry 5nh1 coloured by chain, side view.
PDB entry 5nh1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into Gasdermin D activation from the crystal structure of its C-terminal domain
Anton L, Sborgi L, Hiller S, Broz P, Maier T
Biorxiv (2017)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157625 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gasdermin-D, C-terminal Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 22.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P57764 (Residues: 278-484; Coverage: 43%)
Gene names: DFNA5L, FKSG10, GSDMD, GSDMDC1
Sequence domains: Gasdermin PUB domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 125.73Å b: 47.98Å c: 37.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.231 0.264
Expression system: Escherichia coli BL21(DE3)

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