› 5njx

X-ray diffraction
2.49Å resolution

Human FKBP51 protein in complex with C-terminal peptide of Human HSP 90-alpha

Released:
DOI: 10.2210/pdb5njx/pdb
PDB entry 5njx coloured by chain, front view.
PDB entry 5njx coloured by chain, side view.
PDB entry 5njx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.
Kumar R, Moche M, Winblad B, Pavlov PF
Sci Rep 7 14288 (2017)
PMID: 29079741

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171694 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase FKBP5 Chain: A
Molecule details ›
Chain: A
Length: 462 amino acids
Theoretical weight: 51.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13451 (Residues: 1-457; Coverage: 100%)
Gene names: AIG6, FKBP5, FKBP51
Sequence domains:
HSP90AA1 protein Chain: B
Molecule details ›
Chain: B
Length: 16 amino acids
Theoretical weight: 2.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q96HX7 (Residues: 413-422; Coverage: 2%)
Gene name: HSP90AA1

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P3221
Unit cell:
a: 92.16Å b: 92.16Å c: 132.01Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.195 0.26
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease.
Fries et al. (2017)
1 more

12 mentions without citation

FKBP Ligands-Where We Are and Where to Go?
Kolos et al. (2018)
11 more