› 5np4

X-ray diffraction
1.43Å resolution

Beta domain of human transcobalamin bound to cyanocobalamin

Released:
DOI: 10.2210/pdb5np4/pdb
PDB entry 5np4 coloured by chain, front view.
PDB entry 5np4 coloured by chain, side view.
PDB entry 5np4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human transcobalamin beta domain in four distinct states.
Bloch JS, Ruetz M, Kräutler B, Locher KP
PLoS One 12 e0184932 (2017)
PMID: 28910388

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148829 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcobalamin-2 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 11.97 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P20062 (Residues: 325-427; Coverage: 25%)
Gene names: TC2, TCN2
Sequence domains: Domain of unknown function (DUF4430)
Structure domains: Ferric Hydroxamate Uptake Protein; Chain A, domain 1

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand CNC 1 x CNC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 60.239Å b: 60.239Å c: 69.574Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.158 0.156 0.193
Expression system: Spodoptera frugiperda

Quick links

Citations

2 citation in other articles

Functional and phylogenetic characterization of noncanonical vitamin B12-binding proteins in zebrafish suggests involvement in cobalamin transport.
Benoit et al. (2018)
1 more

1 mention without citation

Structure of the human transcobalamin beta domain in four distinct states.
Bloch et al. (2017)