› 5nqh

X-ray diffraction
2.6Å resolution

Structure of the human Fe65-PTB2 homodimer

Released:
DOI: 10.2210/pdb5nqh/pdb
PDB entry 5nqh coloured by chain, front view.
PDB entry 5nqh coloured by chain, side view.
PDB entry 5nqh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction.
Feilen LP, Haubrich K, Strecker P, Probst S, Eggert S, Stier G, Sinning I, Konietzko U, Kins S, Simon B, Wild K
Front Mol Neurosci 10 140 (2017)
PMID: 28553201

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126159 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid beta precursor protein binding family B member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 140 amino acids
Theoretical weight: 15.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00213 (Residues: 534-667; Coverage: 19%)
Gene names: APBB1, FE65, RIR
Sequence domains: Phosphotyrosine interaction domain (PTB/PID)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

2 bound ligands:
Ligand SO4 6 x SO4
Ligand GOL 5 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 56.578Å b: 104.279Å c: 60.578Å
α: 90° β: 112.04° γ: 90°
R-values:
R R work R free
0.195 0.193 0.24
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance.
Mañucat-Tan et al. (2019)
1 more

1 mention without citation

Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction.
Feilen et al. (2017)