› 5nqw

X-ray diffraction
3.4Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208612 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin heavy constant epsilon Chains: A, B
Molecule details ›
Chains: A, B
Length: 212 amino acids
Theoretical weight: 23.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01854 (Residues: 215-426; Coverage: 39%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
026 Chains: C, D
Molecule details ›
Chains: C, D
Length: 134 amino acids
Theoretical weight: 14.75 KDa
Source organism: Lama glama
Expression system: Escherichia coli

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P41212
Unit cell:
a: 102.02Å b: 102.02Å c: 300.424Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.212 0.241
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

6 review citations

IgE Antibodies: From Structure to Function and Clinical Translation.
Sutton et al. (2019)
5 more

3 mentions without citation

Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction.
Jabs et al. (2018)
2 more