› 5nr4

X-ray diffraction
1.2Å resolution

Crystal structure of Clasp2 TOG1 domain

Released:
DOI: 10.2210/pdb5nr4/pdb
PDB entry 5nr4 coloured by chain, front view.
PDB entry 5nr4 coloured by chain, side view.
PDB entry 5nr4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain.
Aher A, Kok M, Sharma A, Rai A, Olieric N, Rodriguez-Garcia R, Katrukha EA, Weinert T, Olieric V, Kapitein LC, Steinmetz MO, Dogterom M, Akhmanova A
Dev Cell 46 40-58.e8 (2018)
PMID: 29937387

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130837 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CLIP-associating protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 230 amino acids
Theoretical weight: 25.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75122 (Residues: 1111-1180, 1181-1275; Coverage: 13%)
Gene names: CLASP2, KIAA0627

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 66.083Å b: 47.116Å c: 74.152Å
α: 90° β: 115.83° γ: 90°
R-values:
R R work R free
0.2 0.2 0.214
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Rescuing microtubules from the brink of catastrophe: CLASPs lead the way.
Lawrence et al. (2019)
5 more

2 mentions without citation

CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain.
Aher et al. (2018)
1 more