› 5nsd

X-ray diffraction
2.05Å resolution

Function and Biology Details

Reaction catalysed: 
Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155082 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nicotinamide phosphoribosyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 497 amino acids
Theoretical weight: 56.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43490 (Residues: 1-491; Coverage: 100%)
Gene names: NAMPT, PBEF, PBEF1
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

3 bound ligands:
Ligand PO4 2 x PO4
Ligand GOL 14 x GOL
Ligand 96Q 2 x 96Q
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P21
Unit cell:
a: 62.138Å b: 109.167Å c: 84.974Å
α: 90° β: 96.63° γ: 90°
R-values:
R R work R free
0.238 0.235 0.283
Expression system: Escherichia coli

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Citations

24 review citations

Advances in targeting 'undruggable' transcription factors with small molecules.
Henley et al. (2021)
23 more

4 mentions without citation

Progress in the therapeutic inhibition of Cdc42 signalling.
Murphy et al. (2021)
3 more