› 5nuv

X-ray diffraction
1.55Å resolution

Structure of the WD40-domain of human ATG16L1

Released:
DOI: 10.2210/pdb5nuv/pdb
PDB entry 5nuv coloured by chain, front view.
PDB entry 5nuv coloured by chain, side view.
PDB entry 5nuv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the WD40-domain of human ATG16L1.
Bajagic M, Archna A, Büsing P, Scrima A
Protein Sci 26 1828-1837 (2017)
PMID: 28685931

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179295 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Autophagy-related protein 16-1 Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 33.49 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q676U5 (Residues: 303-607; Coverage: 50%)
Gene names: APG16L, ATG16L1, UNQ9393/PRO34307
Sequence domains: WD domain, G-beta repeat

Ligands and Environments

1 bound ligand:
Ligand BU3 1 x BU3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: C2
Unit cell:
a: 157.55Å b: 38.22Å c: 45.62Å
α: 90° β: 105.74° γ: 90°
R-values:
R R work R free
0.167 0.165 0.197
Expression system: Trichoplusia ni

Quick links

Citations

1 review citation

LC3-associated endocytosis and the functions of Rubicon and ATG16L1.
Magné et al. (2022)
7 other articles

3 mentions without citation

The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes.
Fletcher et al. (2018)
2 more