› 5nxc

X-ray diffraction
2.25Å resolution

LIM Domain Kinase 1 (LIMK1) In Complex With PF-00477736

Released:
DOI: 10.2210/pdb5nxc/pdb
PDB entry 5nxc coloured by chain, front view.
PDB entry 5nxc coloured by chain, side view.
PDB entry 5nxc coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mathea S, Salah E, Pike ACW, Bushell S, Carpenter EP, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Bullock AN, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156847 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
LIM domain kinase 1 Chain: L
Molecule details ›
Chain: L
Length: 310 amino acids
Theoretical weight: 35.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53667 (Residues: 330-637; Coverage: 48%)
Gene names: LIMK, LIMK1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 9DB 1 x 9DB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2221
Unit cell:
a: 88.387Å b: 95.836Å c: 84.392Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.239 0.298
Expression system: Spodoptera frugiperda

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