› 5nz9

Solution NMR

NMR structure of an EphA2-Sam fragment

Released:
DOI: 10.2210/pdb5nz9/pdb
PDB entry 5nz9 coloured by chain, ensemble of 20 models, front view.
PDB entry 5nz9 coloured by chain, ensemble of 20 models, side view.
PDB entry 5nz9 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The Sam-Sam interaction between Ship2 and the EphA2 receptor: design and analysis of peptide inhibitors.
Mercurio FA, Di Natale C, Pirone L, Iannitti R, Marasco D, Pedone EM, Palumbo R, Leone M
Sci Rep 7 17474 (2017)
PMID: 29234063

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 2.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P29317 (Residues: 945-969; Coverage: 3%)
Gene names: ECK, EPHA2
Sequence domains: SAM domain (Sterile alpha motif)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 53%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

2 review citations

PTEN and Other PtdIns(3,4,5)P3 Lipid Phosphatases in Breast Cancer.
Csolle et al. (2020)
1 more

2 mentions without citation

Hunting for Novel Routes in Anticancer Drug Discovery: Peptides against Sam-Sam Interactions.
Mercurio et al. (2022)
1 more