› 5o12

X-ray diffraction
2.4Å resolution

Crystal structure of PIM1 kinase in complex with small-molecule inhibitor

Released:
DOI: 10.2210/pdb5o12/pdb
PDB entry 5o12 coloured by chain, front view.
PDB entry 5o12 coloured by chain, side view.
PDB entry 5o12 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors.
Bogusz J, Zrubek K, Rembacz KP, Grudnik P, Golik P, Romanowska M, Wladyka B, Dubin G
Sci Rep 7 13399 (2017)
PMID: 29042609

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 34.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 29-313; Coverage: 91%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 1RO 1 x 1RO
Ligand IMD 1 x IMD
2 modified residues:
Ligand CME 1 x CME
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P65
Unit cell:
a: 97.672Å b: 97.672Å c: 80.579Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.177 0.223
Expression system: Escherichia coli

Quick links

Citations

2 review citations

PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer.
Luszczak et al. (2020)
1 more

4 mentions without citation

Band-gap energy as a descriptor of catalytic activity for propene oxidation over mixed metal oxide catalysts.
Getsoian et al. (2014)
3 more