5o4g

X-ray diffraction
3Å resolution

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-209119 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Receptor tyrosine-protein kinase erbB-2 Chain: C
Molecule details ›
Chain: C
Length: 606 amino acids
Theoretical weight: 66.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04626 (Residues: 23-628; Coverage: 49%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL
Sequence domains:
MF3958 FAB light chain Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
MF3958 FAB heavy chain Chain: B
Molecule details ›
Chain: B
Length: 247 amino acids
Theoretical weight: 26.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 62.79Å b: 113.5Å c: 113.49Å
α: 90° β: 101.92° γ: 90°
R-values:
R R work R free
0.231 0.229 0.271
Expression system: Homo sapiens