› 5o6h

X-ray diffraction
1.29Å resolution

Function and Biology Details

Reaction catalysed: 
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151725 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycylpeptide N-tetradecanoyltransferase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 391 amino acids
Theoretical weight: 45.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30419 (Residues: 109-496; Coverage: 78%)
Gene names: NMT, NMT1
Sequence domains:
Structure domains: Aminopeptidase

Ligands and Environments


Cofactor: Ligand MYA 2 x MYA
5 bound ligands:
Ligand PO4 8 x PO4
Ligand 9M2 2 x 9M2
Ligand MG 2 x MG
Ligand GOL 3 x GOL
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21212
Unit cell:
a: 79.138Å b: 178.852Å c: 58.465Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.164 0.193
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Rhinoviruses and Their Receptors.
Basnet et al. (2019)
15 more

3 mentions without citation

Incorporating Target-Specific Pharmacophoric Information into Deep Generative Models for Fragment Elaboration.
Hadfield et al. (2022)
2 more