› 5o85

X-ray diffraction
3.4Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171832 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
General transcription factor IIH subunit 3 Chains: A, C
Molecule details ›
Chains: A, C
Length: 308 amino acids
Theoretical weight: 34.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13889 (Residues: 1-308; Coverage: 100%)
Gene name: GTF2H3
Sequence domains: Transcription factor Tfb4
General transcription factor IIH subunit 2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 395 amino acids
Theoretical weight: 44.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13888 (Residues: 1-395; Coverage: 100%)
Gene names: BTF2P44, GTF2H2
Sequence domains:
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: I212121
Unit cell:
a: 81.407Å b: 120.388Å c: 128.673Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.24 0.29
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The essential and multifunctional TFIIH complex.
Rimel et al. (2018)
6 other articles

3 mentions without citation

Structural basis of TFIIH activation for nucleotide excision repair.
Kokic et al. (2019)
2 more