› 5ob5

X-ray diffraction
1.65Å resolution

fAb complex with GroBeta. AbVance: increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery.

Released:
DOI: 10.2210/pdb5ob5/pdb
PDB entry 5ob5 coloured by chain, front view.
PDB entry 5ob5 coloured by chain, side view.
PDB entry 5ob5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhao B, Ward P, Convery MA

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210770 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
GRO-beta(5-73) Chain: A
Molecule details ›
Chain: A
Length: 63 amino acids
Theoretical weight: 6.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19875 (Residues: 40-102; Coverage: 86%)
Gene names: CXCL2, GRO2, GROB, MIP2A, SCYB2
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
fAb Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.66 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
fAb Light chain Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand GOL 4 x GOL
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2
Unit cell:
a: 155.19Å b: 60.21Å c: 68.25Å
α: 90° β: 110.44° γ: 90°
R-values:
R R work R free
0.169 0.168 0.195
Expression systems:
  • Escherichia coli
  • Cricetulus griseus

Quick links