› 5oeh

X-ray diffraction
2.35Å resolution

Molecular tweezers modulate 14-3-3 protein-protein interactions.

Released:
DOI: 10.2210/pdb5oeh/pdb
PDB entry 5oeh coloured by chain, front view.
PDB entry 5oeh coloured by chain, side view.
PDB entry 5oeh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular tweezers modulate 14-3-3 protein-protein interactions.
Bier D, Rose R, Bravo-Rodriguez K, Bartel M, Ramirez-Anguita JM, Dutt S, Wilch C, Klärner FG, Sanchez-Garcia E, Schrader T, Ottmann C
Nat Chem 5 234-9 (2013)
PMID: 23422566

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
14-3-3 protein sigma Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 26.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31947 (Residues: 1-231; Coverage: 93%)
Gene names: HME1, SFN
Sequence domains: 14-3-3 protein
Structure domains: 14-3-3 domain

Ligands and Environments

3 bound ligands:
Ligand 9SZ 1 x 9SZ
Ligand CL 1 x CL
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C222
Unit cell:
a: 60.4Å b: 157.4Å c: 77.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.202 0.264
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Artificial Molecular Machines.
Erbas-Cakmak et al. (2015)
13 more

4 mentions without citation

14-3-3σ and Its Modulators in Cancer.
Aljabal et al. (2020)
3 more