› 5oek

Solution NMR

Putative active dimeric state of GHR transmembrane domain

Released:
DOI: 10.2210/pdb5oek/pdb
PDB entry 5oek coloured by chain, ensemble of 20 models, front view.
PDB entry 5oek coloured by chain, ensemble of 20 models, side view.
PDB entry 5oek coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the signal transduction via transmembrane domain of the human growth hormone receptor.
Bocharov EV, Lesovoy DM, Bocharova OV, Urban AS, Pavlov KV, Volynsky PE, Efremov RG, Arseniev AS
Biochim Biophys Acta Gen Subj 1862 1410-1420 (2018)
PMID: 29571748

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145518 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth hormone-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 43 amino acids
Theoretical weight: 5.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P10912 (Residues: 254-294; Coverage: 7%)
Gene name: GHR

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 49%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

5 review citations

The transition model of RTK activation: A quantitative framework for understanding RTK signaling and RTK modulator activity.
Paul et al. (2019)
4 more

2 mentions without citation

Order and disorder-An integrative structure of the full-length human growth hormone receptor.
Kassem et al. (2021)
1 more