› 5ojk

X-ray diffraction
2.55Å resolution

Crystal structure of the human neuroligin 1 cholinesterase domain containing spliced sequence B (SSB) (NL1(-A+B))

Released:
DOI: 10.2210/pdb5ojk/pdb
PDB entry 5ojk coloured by chain, front view.
PDB entry 5ojk coloured by chain, side view.
PDB entry 5ojk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.
Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, de Wit J, Begbie J, Craig AM, Aricescu AR
Neuron 95 896-913.e10 (2017)
PMID: 28817804

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuroligin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 585 amino acids
Theoretical weight: 65.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N2Q7 (Residues: 46-658; Coverage: 70%)
Gene names: KIAA1070, NLGN1
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand PGE 4 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Unit cell:
a: 49.57Å b: 118.05Å c: 214.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.278
Expression system: Homo sapiens

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Citations

12 review citations

Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits.
Südhof TC. (2017)
11 more

1 mention without citation

Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.
Elegheert et al. (2017)