Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Neurotransmitter-gated ion-channel
- Gamma-aminobutyric acid A receptor/Glycine receptor alpha
- Gamma-aminobutyric-acid A receptor, beta subunit
- Immunoglobulin V-set domain
- Neurotransmitter-gated ion-channel ligand-binding domain superfamily
- Immunoglobulin subtype
- Immunoglobulin-like domain superfamily
- Immunoglobulin-like fold
7 more domains
Structure analysis Details
Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210963 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Gamma-aminobutyric acid receptor subunit alpha-5; Gamma-aminobutyric acid receptor subunit beta-3
Molecule details ›
Chains: A, B, C, D, E
Length: 395 amino acids
Theoretical weight: 44.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 395 amino acids
Theoretical weight: 44.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P31644 (Residues: 16-18, 21-23, 29-30, 261-346, 424-462; Coverage: 27%) - Canonical: P28472 (Residues: 9-10, 14-18, 21-246; Coverage: 48%)
Sequence domains:
- Neurotransmitter-gated ion-channel ligand binding domain
- Neurotransmitter-gated ion-channel transmembrane region
Ligands and Environments
1 bound ligand:
No modified residues
Experiments and Validation Details
X-ray source:
DIAMOND BEAMLINE I04
Spacegroup:
C2
Expression systems:
- Homo sapiens
- Escherichia coli
