› 5oqv

Electron Microscopy
4Å resolution

Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM

Released:
DOI: 10.2210/pdb5oqv/pdb
PDB entry 5oqv coloured by chain, front view.
PDB entry 5oqv coloured by chain, side view.
PDB entry 5oqv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fibril structure of amyloid-β(1-42) by cryo-electron microscopy.
Gremer L, Schölzel D, Schenk C, Reinartz E, Labahn J, Ravelli RBG, Tusche M, Lopez-Iglesias C, Hoyer W, Heise H, Willbold D, Schröder GF
Science 358 116-119 (2017)
PMID: 28882996
Related structures: EMD-3851

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 42 Chains: A, B, C, D, E, F, G, H, I
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I
Length: 42 amino acids
Theoretical weight: 4.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 672-713; Coverage: 6%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-3851
Expression system: Escherichia coli

Quick links

Citations

87 review citations

Alzheimer's disease.
Scheltens et al. (2021)
86 more

79 mentions without citation

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.
Nguyen et al. (2021)
78 more