› 5ott

X-ray diffraction
1.92Å resolution

Extracellular domain of GLP-1 receptor in complex with exendin-4 variant Gly2Hcs/Thr5Hcs

Released:
DOI: 10.2210/pdb5ott/pdb
PDB entry 5ott coloured by chain, front view.
PDB entry 5ott coloured by chain, side view.
PDB entry 5ott coloured by chain, top view.
Source organisms:
Primary publication:
α-Helix or β-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
Oddo A, Mortensen S, Thøgersen H, De Maria L, Hennen S, McGuire JN, Kofoed J, Linderoth L, Reedtz-Runge S
Biochemistry 57 4148-4154 (2018)
PMID: 29877701

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150708 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glucagon-like peptide 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43220 (Residues: 24-139; Coverage: 26%)
Gene name: GLP1R
Sequence domains: Hormone receptor domain
Exendin-4 Chain: B
Molecule details ›
Chain: B
Length: 39 amino acids
Theoretical weight: 4.27 KDa
Source organism: Heloderma suspectum
Expression system: Not provided
UniProt:
  • Canonical: P26349 (Residues: 48-86; Coverage: 61%)
Sequence domains: Peptide hormone

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-X
Spacegroup: I222
Unit cell:
a: 51.69Å b: 62.92Å c: 118.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.209
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

The Discovery and Development of Liraglutide and Semaglutide.
Knudsen et al. (2019)
7 other articles