› 5ovr

X-ray diffraction
2.15Å resolution

X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors

Released:
DOI: 10.2210/pdb5ovr/pdb
PDB entry 5ovr coloured by chain, front view.
PDB entry 5ovr coloured by chain, side view.
PDB entry 5ovr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
Witten MR, Wissler L, Snow M, Geschwindner S, Read JA, Brandon NJ, Nairn AC, Lombroso PJ, Käck H, Ellman JA
J Med Chem 60 9299-9319 (2017)
PMID: 29116812

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157113 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 5 Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 35.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P54829 (Residues: 282-561; Coverage: 50%)
Gene name: PTPN5
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand AXK 1 x AXK
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 52.5Å b: 64.32Å c: 100.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.214 0.291
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer's Disease and Other Neurological Disorders.
Mahaman et al. (2021)
1 more

3 mentions without citation

X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
Witten et al. (2017)
2 more