5ow1

X-ray diffraction
2.05Å resolution

X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-157113 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 5 Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 35.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P54829 (Residues: 282-563; Coverage: 50%)
Gene name: PTPN5
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 52.66Å b: 64.41Å c: 100.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.212
Expression system: Escherichia coli